German Oncological Data Standard (GOLD) - Local Development build (v0.1.0) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

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Resource Profile: Profile Tumor Specimen

Profile of a tumor specimen

Usage:

• Examples for this Resource Profile: Specimen/blood-specimen

Formal Views of Profile Content

Description of Profiles, Differentials, Snapshots and how the different presentations work.

• Differential Table
• Key Elements Table
• Snapshot Table
• Statistics/References
• All

This structure is derived from ProfileSpecimenBioprobeCore

Name	Flags	Card.	Type	Description & Constraints
Specimen		0..*	ProfileSpecimenBioprobeCore	Sample for analysis
partOf	S	0..*	Reference(Profile Tumor)	Specimen part of Tumor URL: https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of
identifier		1..*	Identifier	External Identifier
collection
bodySite		1..1	CodeableConcept	Anatomical collection site
Documentation for this format

Name	Flags	Card.	Type	Description & Constraints
Specimen		0..*	ProfileSpecimenBioprobeCore	Sample for analysis
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
partOf	S	0..*	Reference(Profile Tumor)	Specimen part of Tumor URL: https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of
modifierExtension	?!N	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
identifier	SΣ	1..*	Identifier	External Identifier
status	?!SΣ	1..1	code	available | unavailable | unsatisfactory | entered-in-error Binding: SpecimenStatus (required): Codes providing the status/availability of a specimen.
type	SΣ	1..1	CodeableConcept	Kind of material that forms the specimen Binding: hl7VS-specimenType (example): The type of the specimen.
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	ΣN	1..*	Coding	Code defined by a terminology system Binding: ValueSet - Probenart (extensible)
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
subject	SΣC	1..1	Reference(Patient)	Where the specimen came from. This may be from patient(s), from a location (e.g., the source of an environmental sample), or a sampling of a substance or a device
parent	SC	0..*	Reference(Specimen)	Specimen from which this specimen originated
request	SC	0..*	Reference(ServiceRequest)	Why the specimen was collected
collection	S	1..1	BackboneElement	Collection details
einstellungBlutversorgung	SN	0..1	dateTime	Extension - Einstellung Blutversorgung URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/EinstellungBlutversorgung
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
collected[x]	SΣ	1..1		Collection time
collectedDateTime			dateTime
collectedPeriod			Period
bodySite	SC	1..1	CodeableConcept	Anatomical collection site Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.
Slices for coding	ΣN	0..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - SNOMED CT Body Strutures (required)
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
coding:icd-o-3	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - ICD-O-3 Topography (required)
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://terminology.hl7.org/CodeSystem/icd-o-3
Slices for fastingStatus[x]	SΣN	0..1		Whether or how long patient abstained from food and/or drink Slice: Unordered, Open by type:$this Binding: hl7VS-relevantClincialInformation (extensible): Codes describing the fasting status of the patient.
fastingStatusCodeableConcept			CodeableConcept
fastingStatusDuration			Duration
fastingStatus[x]:fastingStatusCodeableConcept	ΣN	0..1	CodeableConcept	Whether or how long patient abstained from food and/or drink Binding: hl7VS-relevantClincialInformation (required): Codes describing the fasting status of the patient.
Slices for processing	SN	0..*	BackboneElement	Processing and processing step details Slice: Unordered, Open by pattern:processing.procedure.coding
processing:All Slices				Content/Rules for all slices
Slices for extension	N	1..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
procedure	SN	1..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: ValueSet - SNOMED CT Laboratory Procedure (example): Type indicating the technique used to process the specimen.
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	1..*	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
additive	SCN	0..*	Reference(Profile - Substance - Additiv)	Material used in the processing step
Slices for time[x]	SN	0..1		Date and time of specimen processing Slice: Unordered, Open by type:$this
timeDateTime			dateTime
timePeriod			Period
time[x]:timePeriod	SN	0..1	Period	Date and time of specimen processing
start	SΣCN	0..1	dateTime	Starting time with inclusive boundary
end	SΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
processing:lagerprozess	SN	0..*	BackboneElement	Processing and processing step details
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
time[x]	N	1..1	Period	Date and time of specimen processing
time[x]:timePeriod	N	0..1	Period	Date and time of specimen processing
start	ΣCN	1..1	dateTime	Starting time with inclusive boundary
end	ΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
container	S	0..*	BackboneElement	Direct container of specimen (tube/slide, etc.)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	S	1..1	CodeableConcept	Kind of container directly associated with specimen Binding: ValueSet - Containertyp (extensible): Type of specimen container.
capacity	SC	0..1	SimpleQuantity	Container volume or size
specimenQuantity	SC	0..1	SimpleQuantity	Quantity of specimen within container
additive[x]	S	0..1	Reference(Profile - Substance - Additiv)	Additive associated with container Binding: hl7VS-additivePreservative (example): Substance added to specimen container.
note	S	0..*	Annotation	Comments
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet
Specimen.status	required	SpecimenStatus
Specimen.type	example	Hl7VSSpecimenType
Specimen.type.coding:sct	extensible	ValueSetProbenart
Specimen.collection.bodySite	example	SNOMEDCTBodyStructures
Specimen.collection.bodySite.coding:sct	required	ValueSetSCTBodyStructures
Specimen.collection.bodySite.coding:icd-o-3	required	ValueSetICDO3Topography
Specimen.collection.fastingStatus[x]	extensible	Hl7VSRelevantClincialInformation
Specimen.collection.fastingStatus[x]:fastingStatusCodeableConcept	required	Hl7VSRelevantClincialInformation
Specimen.processing.procedure	example	ValueSetSCTLaboratoryProcedure
Specimen.container.type	extensible	ValueSetContainertyp
Specimen.container.additive[x]	example	Hl7VSAdditivePreservative

Constraints

Id	Grade	Path(s)	Details	Requirements
dom-2	error	Specimen	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Specimen	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Specimen	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** elements	Must have either extensions or value[x], not both : extension.exists() != value.exists()
mii-bb-1	error	Specimen.collection.bodySite	Bei der Angabe der Entnahmestelle muss ein ICD-O-3 Topographiecode oder ein SNOMED CT Code angegeben werden. : coding.where(system = 'http://snomed.info/sct' or system = 'http://terminology.hl7.org/CodeSystem/icd-o-3').exists()
qty-3	error	Specimen.container.capacity, Specimen.container.specimenQuantity	If a code for the unit is present, the system SHALL also be present : code.empty() or system.exists()
ref-1	error	Specimen.subject, Specimen.parent, Specimen.request, Specimen.processing.additive	SHALL have a contained resource if a local reference is provided : reference.startsWith('#').not() or (reference.substring(1).trace('url') in %rootResource.contained.id.trace('ids'))
sqty-1	error	Specimen.container.capacity, Specimen.container.specimenQuantity	The comparator is not used on a SimpleQuantity : comparator.empty()

Name	Flags	Card.	Type	Description & Constraints
Specimen		0..*	ProfileSpecimenBioprobeCore	Sample for analysis
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: CommonLanguages (preferred): A human language. Additional Bindings Purpose AllLanguages Max Binding
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
Slices for extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
partOf	S	0..*	Reference(Profile Tumor)	Specimen part of Tumor URL: https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of
modifierExtension	?!N	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
identifier	SΣ	1..*	Identifier	External Identifier
accessionIdentifier	Σ	0..1	Identifier	Identifier assigned by the lab
status	?!SΣ	1..1	code	available | unavailable | unsatisfactory | entered-in-error Binding: SpecimenStatus (required): Codes providing the status/availability of a specimen.
type	SΣ	1..1	CodeableConcept	Kind of material that forms the specimen Binding: hl7VS-specimenType (example): The type of the specimen.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	ΣN	1..*	Coding	Code defined by a terminology system Binding: ValueSet - Probenart (extensible)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	ΣN	0..1	string	Version of the system - if relevant
code	ΣN	0..1	code	Symbol in syntax defined by the system
display	ΣN	0..1	string	Representation defined by the system
userSelected	ΣN	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
subject	SΣC	1..1	Reference(Patient)	Where the specimen came from. This may be from patient(s), from a location (e.g., the source of an environmental sample), or a sampling of a substance or a device
receivedTime	Σ	0..1	dateTime	The time when specimen was received for processing
parent	SC	0..*	Reference(Specimen)	Specimen from which this specimen originated
request	SC	0..*	Reference(ServiceRequest)	Why the specimen was collected
collection	S	1..1	BackboneElement	Collection details
id		0..1	string	Unique id for inter-element referencing
Slices for extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
einstellungBlutversorgung	SN	0..1	dateTime	Extension - Einstellung Blutversorgung URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/EinstellungBlutversorgung
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
collector	ΣC	0..1	Reference(Practitioner | PractitionerRole)	Who collected the specimen
collected[x]	SΣ	1..1		Collection time
collectedDateTime			dateTime
collectedPeriod			Period
duration	ΣC	0..1	Duration	How long it took to collect specimen Binding: CommonUCUMCodesForDuration (extensible): Appropriate units for Duration. Additional Bindings Purpose AllUCUMExpressionForTime Max Binding
quantity	C	0..1	SimpleQuantity	The quantity of specimen collected
method		0..1	CodeableConcept	Technique used to perform collection Binding: FHIRSpecimenCollectionMethod (example): The technique that is used to perform the procedure.
bodySite	SC	1..1	CodeableConcept	Anatomical collection site Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	ΣN	0..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - SNOMED CT Body Strutures (required)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	ΣN	0..1	string	Version of the system - if relevant
code	ΣN	0..1	code	Symbol in syntax defined by the system
display	ΣN	0..1	string	Representation defined by the system
userSelected	ΣN	0..1	boolean	If this coding was chosen directly by the user
coding:icd-o-3	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - ICD-O-3 Topography (required)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://terminology.hl7.org/CodeSystem/icd-o-3
version	ΣN	0..1	string	Version of the system - if relevant
code	ΣN	0..1	code	Symbol in syntax defined by the system
display	ΣN	0..1	string	Representation defined by the system
userSelected	ΣN	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
Slices for fastingStatus[x]	SΣN	0..1		Whether or how long patient abstained from food and/or drink Slice: Unordered, Open by type:$this Binding: hl7VS-relevantClincialInformation (extensible): Codes describing the fasting status of the patient.
fastingStatusCodeableConcept			CodeableConcept
fastingStatusDuration			Duration
fastingStatus[x]:fastingStatusCodeableConcept	ΣN	0..1	CodeableConcept	Whether or how long patient abstained from food and/or drink Binding: hl7VS-relevantClincialInformation (required): Codes describing the fasting status of the patient.
Slices for processing	SN	0..*	BackboneElement	Processing and processing step details Slice: Unordered, Open by pattern:processing.procedure.coding
processing:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension	N	1..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	N	0..1	string	Textual description of procedure
procedure	SN	1..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: ValueSet - SNOMED CT Laboratory Procedure (example): Type indicating the technique used to process the specimen.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	1..*	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	ΣN	0..1	string	Plain text representation of the concept
additive	SCN	0..*	Reference(Profile - Substance - Additiv)	Material used in the processing step
Slices for time[x]	SN	0..1		Date and time of specimen processing Slice: Unordered, Open by type:$this
timeDateTime			dateTime
timePeriod			Period
time[x]:timePeriod	SN	0..1	Period	Date and time of specimen processing
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
start	SΣCN	0..1	dateTime	Starting time with inclusive boundary
end	SΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
processing:lagerprozess	SN	0..*	BackboneElement	Processing and processing step details
id		0..1	string	Unique id for inter-element referencing
Slices for extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	N	0..1	string	Textual description of procedure
procedure	N	0..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: SpecimenProcessingProcedure (example): Type indicating the technique used to process the specimen.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	ΣN	0..*	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: 1186936003
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	ΣN	0..1	string	Plain text representation of the concept
additive	CN	0..*	Reference(Substance)	Material used in the processing step
time[x]	N	1..1	Period	Date and time of specimen processing
time[x]:timePeriod	N	0..1	Period	Date and time of specimen processing
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
start	ΣCN	1..1	dateTime	Starting time with inclusive boundary
end	ΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
container	S	0..*	BackboneElement	Direct container of specimen (tube/slide, etc.)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
identifier	Σ	0..*	Identifier	Id for the container
description		0..1	string	Textual description of the container
type	S	1..1	CodeableConcept	Kind of container directly associated with specimen Binding: ValueSet - Containertyp (extensible): Type of specimen container.
capacity	SC	0..1	SimpleQuantity	Container volume or size
specimenQuantity	SC	0..1	SimpleQuantity	Quantity of specimen within container
additive[x]	S	0..1	Reference(Profile - Substance - Additiv)	Additive associated with container Binding: hl7VS-additivePreservative (example): Substance added to specimen container.
condition	Σ	0..*	CodeableConcept	State of the specimen Binding: hl7VS-specimenCondition (extensible): Codes describing the state of the specimen.
note	S	0..*	Annotation	Comments
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet
Specimen.language	preferred	CommonLanguages Additional Bindings Purpose AllLanguages Max Binding
Specimen.status	required	SpecimenStatus
Specimen.type	example	Hl7VSSpecimenType
Specimen.type.coding:sct	extensible	ValueSetProbenart
Specimen.collection.duration	extensible	CommonUCUMCodesForDuration Additional Bindings Purpose AllUCUMExpressionForTime Max Binding
Specimen.collection.method	example	FHIRSpecimenCollectionMethod
Specimen.collection.bodySite	example	SNOMEDCTBodyStructures
Specimen.collection.bodySite.coding:sct	required	ValueSetSCTBodyStructures
Specimen.collection.bodySite.coding:icd-o-3	required	ValueSetICDO3Topography
Specimen.collection.fastingStatus[x]	extensible	Hl7VSRelevantClincialInformation
Specimen.collection.fastingStatus[x]:fastingStatusCodeableConcept	required	Hl7VSRelevantClincialInformation
Specimen.processing.procedure	example	ValueSetSCTLaboratoryProcedure
Specimen.processing:lagerprozess.procedure	example	SpecimenProcessingProcedure
Specimen.container.type	extensible	ValueSetContainertyp
Specimen.container.additive[x]	example	Hl7VSAdditivePreservative
Specimen.condition	extensible	Hl7VSSpecimenCondition

Constraints

Id	Grade	Path(s)	Details	Requirements
dom-2	error	Specimen	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Specimen	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Specimen	A resource should have narrative for robust management : text.`div`.exists()
drt-1	error	Specimen.collection.duration	There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. : code.exists() implies ((system = %ucum) and value.exists())
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** elements	Must have either extensions or value[x], not both : extension.exists() != value.exists()
mii-bb-1	error	Specimen.collection.bodySite	Bei der Angabe der Entnahmestelle muss ein ICD-O-3 Topographiecode oder ein SNOMED CT Code angegeben werden. : coding.where(system = 'http://snomed.info/sct' or system = 'http://terminology.hl7.org/CodeSystem/icd-o-3').exists()
qty-3	error	Specimen.collection.duration, Specimen.collection.quantity, Specimen.container.capacity, Specimen.container.specimenQuantity	If a code for the unit is present, the system SHALL also be present : code.empty() or system.exists()
ref-1	error	Specimen.subject, Specimen.parent, Specimen.request, Specimen.collection.collector, Specimen.processing.additive, Specimen.processing:lagerprozess.additive	SHALL have a contained resource if a local reference is provided : reference.startsWith('#').not() or (reference.substring(1).trace('url') in %rootResource.contained.id.trace('ids'))
sqty-1	error	Specimen.collection.quantity, Specimen.container.capacity, Specimen.container.specimenQuantity	The comparator is not used on a SimpleQuantity : comparator.empty()

This structure is derived from ProfileSpecimenBioprobeCore

Summary

Mandatory: 2 elements
Must-Support: 1 element

Extensions

This structure refers to these extensions:

• https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of

Differential View

This structure is derived from ProfileSpecimenBioprobeCore

Name	Flags	Card.	Type	Description & Constraints
Specimen		0..*	ProfileSpecimenBioprobeCore	Sample for analysis
partOf	S	0..*	Reference(Profile Tumor)	Specimen part of Tumor URL: https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of
identifier		1..*	Identifier	External Identifier
collection
bodySite		1..1	CodeableConcept	Anatomical collection site
Documentation for this format

Key Elements View

Name	Flags	Card.	Type	Description & Constraints
Specimen		0..*	ProfileSpecimenBioprobeCore	Sample for analysis
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
partOf	S	0..*	Reference(Profile Tumor)	Specimen part of Tumor URL: https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of
modifierExtension	?!N	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
identifier	SΣ	1..*	Identifier	External Identifier
status	?!SΣ	1..1	code	available | unavailable | unsatisfactory | entered-in-error Binding: SpecimenStatus (required): Codes providing the status/availability of a specimen.
type	SΣ	1..1	CodeableConcept	Kind of material that forms the specimen Binding: hl7VS-specimenType (example): The type of the specimen.
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	ΣN	1..*	Coding	Code defined by a terminology system Binding: ValueSet - Probenart (extensible)
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
subject	SΣC	1..1	Reference(Patient)	Where the specimen came from. This may be from patient(s), from a location (e.g., the source of an environmental sample), or a sampling of a substance or a device
parent	SC	0..*	Reference(Specimen)	Specimen from which this specimen originated
request	SC	0..*	Reference(ServiceRequest)	Why the specimen was collected
collection	S	1..1	BackboneElement	Collection details
einstellungBlutversorgung	SN	0..1	dateTime	Extension - Einstellung Blutversorgung URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/EinstellungBlutversorgung
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
collected[x]	SΣ	1..1		Collection time
collectedDateTime			dateTime
collectedPeriod			Period
bodySite	SC	1..1	CodeableConcept	Anatomical collection site Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.
Slices for coding	ΣN	0..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - SNOMED CT Body Strutures (required)
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
coding:icd-o-3	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - ICD-O-3 Topography (required)
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://terminology.hl7.org/CodeSystem/icd-o-3
Slices for fastingStatus[x]	SΣN	0..1		Whether or how long patient abstained from food and/or drink Slice: Unordered, Open by type:$this Binding: hl7VS-relevantClincialInformation (extensible): Codes describing the fasting status of the patient.
fastingStatusCodeableConcept			CodeableConcept
fastingStatusDuration			Duration
fastingStatus[x]:fastingStatusCodeableConcept	ΣN	0..1	CodeableConcept	Whether or how long patient abstained from food and/or drink Binding: hl7VS-relevantClincialInformation (required): Codes describing the fasting status of the patient.
Slices for processing	SN	0..*	BackboneElement	Processing and processing step details Slice: Unordered, Open by pattern:processing.procedure.coding
processing:All Slices				Content/Rules for all slices
Slices for extension	N	1..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
procedure	SN	1..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: ValueSet - SNOMED CT Laboratory Procedure (example): Type indicating the technique used to process the specimen.
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	1..*	Coding	Code defined by a terminology system Required Pattern: At least the following
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
additive	SCN	0..*	Reference(Profile - Substance - Additiv)	Material used in the processing step
Slices for time[x]	SN	0..1		Date and time of specimen processing Slice: Unordered, Open by type:$this
timeDateTime			dateTime
timePeriod			Period
time[x]:timePeriod	SN	0..1	Period	Date and time of specimen processing
start	SΣCN	0..1	dateTime	Starting time with inclusive boundary
end	SΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
processing:lagerprozess	SN	0..*	BackboneElement	Processing and processing step details
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
time[x]	N	1..1	Period	Date and time of specimen processing
time[x]:timePeriod	N	0..1	Period	Date and time of specimen processing
start	ΣCN	1..1	dateTime	Starting time with inclusive boundary
end	ΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
container	S	0..*	BackboneElement	Direct container of specimen (tube/slide, etc.)
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
type	S	1..1	CodeableConcept	Kind of container directly associated with specimen Binding: ValueSet - Containertyp (extensible): Type of specimen container.
capacity	SC	0..1	SimpleQuantity	Container volume or size
specimenQuantity	SC	0..1	SimpleQuantity	Quantity of specimen within container
additive[x]	S	0..1	Reference(Profile - Substance - Additiv)	Additive associated with container Binding: hl7VS-additivePreservative (example): Substance added to specimen container.
note	S	0..*	Annotation	Comments
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet
Specimen.status	required	SpecimenStatus
Specimen.type	example	Hl7VSSpecimenType
Specimen.type.coding:sct	extensible	ValueSetProbenart
Specimen.collection.bodySite	example	SNOMEDCTBodyStructures
Specimen.collection.bodySite.coding:sct	required	ValueSetSCTBodyStructures
Specimen.collection.bodySite.coding:icd-o-3	required	ValueSetICDO3Topography
Specimen.collection.fastingStatus[x]	extensible	Hl7VSRelevantClincialInformation
Specimen.collection.fastingStatus[x]:fastingStatusCodeableConcept	required	Hl7VSRelevantClincialInformation
Specimen.processing.procedure	example	ValueSetSCTLaboratoryProcedure
Specimen.container.type	extensible	ValueSetContainertyp
Specimen.container.additive[x]	example	Hl7VSAdditivePreservative

Constraints

Id	Grade	Path(s)	Details	Requirements
dom-2	error	Specimen	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Specimen	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Specimen	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** elements	Must have either extensions or value[x], not both : extension.exists() != value.exists()
mii-bb-1	error	Specimen.collection.bodySite	Bei der Angabe der Entnahmestelle muss ein ICD-O-3 Topographiecode oder ein SNOMED CT Code angegeben werden. : coding.where(system = 'http://snomed.info/sct' or system = 'http://terminology.hl7.org/CodeSystem/icd-o-3').exists()
qty-3	error	Specimen.container.capacity, Specimen.container.specimenQuantity	If a code for the unit is present, the system SHALL also be present : code.empty() or system.exists()
ref-1	error	Specimen.subject, Specimen.parent, Specimen.request, Specimen.processing.additive	SHALL have a contained resource if a local reference is provided : reference.startsWith('#').not() or (reference.substring(1).trace('url') in %rootResource.contained.id.trace('ids'))
sqty-1	error	Specimen.container.capacity, Specimen.container.specimenQuantity	The comparator is not used on a SimpleQuantity : comparator.empty()

Snapshot View

Name	Flags	Card.	Type	Description & Constraints
Specimen		0..*	ProfileSpecimenBioprobeCore	Sample for analysis
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: CommonLanguages (preferred): A human language. Additional Bindings Purpose AllLanguages Max Binding
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
Slices for extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
partOf	S	0..*	Reference(Profile Tumor)	Specimen part of Tumor URL: https://www.vision-zero-oncology.de/fhir/StructureDefinition/part-of
modifierExtension	?!N	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
identifier	SΣ	1..*	Identifier	External Identifier
accessionIdentifier	Σ	0..1	Identifier	Identifier assigned by the lab
status	?!SΣ	1..1	code	available | unavailable | unsatisfactory | entered-in-error Binding: SpecimenStatus (required): Codes providing the status/availability of a specimen.
type	SΣ	1..1	CodeableConcept	Kind of material that forms the specimen Binding: hl7VS-specimenType (example): The type of the specimen.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	ΣN	1..*	Coding	Code defined by a terminology system Binding: ValueSet - Probenart (extensible)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	ΣN	0..1	string	Version of the system - if relevant
code	ΣN	0..1	code	Symbol in syntax defined by the system
display	ΣN	0..1	string	Representation defined by the system
userSelected	ΣN	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
subject	SΣC	1..1	Reference(Patient)	Where the specimen came from. This may be from patient(s), from a location (e.g., the source of an environmental sample), or a sampling of a substance or a device
receivedTime	Σ	0..1	dateTime	The time when specimen was received for processing
parent	SC	0..*	Reference(Specimen)	Specimen from which this specimen originated
request	SC	0..*	Reference(ServiceRequest)	Why the specimen was collected
collection	S	1..1	BackboneElement	Collection details
id		0..1	string	Unique id for inter-element referencing
Slices for extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
einstellungBlutversorgung	SN	0..1	dateTime	Extension - Einstellung Blutversorgung URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/EinstellungBlutversorgung
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
collector	ΣC	0..1	Reference(Practitioner | PractitionerRole)	Who collected the specimen
collected[x]	SΣ	1..1		Collection time
collectedDateTime			dateTime
collectedPeriod			Period
duration	ΣC	0..1	Duration	How long it took to collect specimen Binding: CommonUCUMCodesForDuration (extensible): Appropriate units for Duration. Additional Bindings Purpose AllUCUMExpressionForTime Max Binding
quantity	C	0..1	SimpleQuantity	The quantity of specimen collected
method		0..1	CodeableConcept	Technique used to perform collection Binding: FHIRSpecimenCollectionMethod (example): The technique that is used to perform the procedure.
bodySite	SC	1..1	CodeableConcept	Anatomical collection site Binding: SNOMEDCTBodyStructures (example): Codes describing anatomical locations. May include laterality.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	ΣN	0..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - SNOMED CT Body Strutures (required)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	ΣN	0..1	string	Version of the system - if relevant
code	ΣN	0..1	code	Symbol in syntax defined by the system
display	ΣN	0..1	string	Representation defined by the system
userSelected	ΣN	0..1	boolean	If this coding was chosen directly by the user
coding:icd-o-3	SΣN	0..1	Coding	Code defined by a terminology system Binding: ValueSet - ICD-O-3 Topography (required)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	ΣN	1..1	uri	Identity of the terminology system Required Pattern: http://terminology.hl7.org/CodeSystem/icd-o-3
version	ΣN	0..1	string	Version of the system - if relevant
code	ΣN	0..1	code	Symbol in syntax defined by the system
display	ΣN	0..1	string	Representation defined by the system
userSelected	ΣN	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
Slices for fastingStatus[x]	SΣN	0..1		Whether or how long patient abstained from food and/or drink Slice: Unordered, Open by type:$this Binding: hl7VS-relevantClincialInformation (extensible): Codes describing the fasting status of the patient.
fastingStatusCodeableConcept			CodeableConcept
fastingStatusDuration			Duration
fastingStatus[x]:fastingStatusCodeableConcept	ΣN	0..1	CodeableConcept	Whether or how long patient abstained from food and/or drink Binding: hl7VS-relevantClincialInformation (required): Codes describing the fasting status of the patient.
Slices for processing	SN	0..*	BackboneElement	Processing and processing step details Slice: Unordered, Open by pattern:processing.procedure.coding
processing:All Slices				Content/Rules for all slices
id		0..1	string	Unique id for inter-element referencing
Slices for extension	N	1..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	N	0..1	string	Textual description of procedure
procedure	SN	1..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: ValueSet - SNOMED CT Laboratory Procedure (example): Type indicating the technique used to process the specimen.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	ΣN	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by pattern:system
coding:sct	SΣN	1..*	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
version		0..1	string	Version of the system - if relevant
code		0..1	code	Symbol in syntax defined by the system
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	ΣN	0..1	string	Plain text representation of the concept
additive	SCN	0..*	Reference(Profile - Substance - Additiv)	Material used in the processing step
Slices for time[x]	SN	0..1		Date and time of specimen processing Slice: Unordered, Open by type:$this
timeDateTime			dateTime
timePeriod			Period
time[x]:timePeriod	SN	0..1	Period	Date and time of specimen processing
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
start	SΣCN	0..1	dateTime	Starting time with inclusive boundary
end	SΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
processing:lagerprozess	SN	0..*	BackboneElement	Processing and processing step details
id		0..1	string	Unique id for inter-element referencing
Slices for extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
temperaturbedingungen	SN	1..1	Range	Extension - Temperaturbedingungen URL: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
modifierExtension	?!ΣN	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	N	0..1	string	Textual description of procedure
procedure	N	0..1	CodeableConcept	Indicates the treatment step applied to the specimen Binding: SpecimenProcessingProcedure (example): Type indicating the technique used to process the specimen.
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
coding	ΣN	0..*	Coding	Code defined by a terminology system Required Pattern: At least the following
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
system		1..1	uri	Identity of the terminology system Fixed Value: http://snomed.info/sct
version		0..1	string	Version of the system - if relevant
code		1..1	code	Symbol in syntax defined by the system Fixed Value: 1186936003
display		0..1	string	Representation defined by the system
userSelected		0..1	boolean	If this coding was chosen directly by the user
text	ΣN	0..1	string	Plain text representation of the concept
additive	CN	0..*	Reference(Substance)	Material used in the processing step
time[x]	N	1..1	Period	Date and time of specimen processing
time[x]:timePeriod	N	0..1	Period	Date and time of specimen processing
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
start	ΣCN	1..1	dateTime	Starting time with inclusive boundary
end	ΣCN	0..1	dateTime	End time with inclusive boundary, if not ongoing
container	S	0..*	BackboneElement	Direct container of specimen (tube/slide, etc.)
id		0..1	string	Unique id for inter-element referencing
extension	N	0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
identifier	Σ	0..*	Identifier	Id for the container
description		0..1	string	Textual description of the container
type	S	1..1	CodeableConcept	Kind of container directly associated with specimen Binding: ValueSet - Containertyp (extensible): Type of specimen container.
capacity	SC	0..1	SimpleQuantity	Container volume or size
specimenQuantity	SC	0..1	SimpleQuantity	Quantity of specimen within container
additive[x]	S	0..1	Reference(Profile - Substance - Additiv)	Additive associated with container Binding: hl7VS-additivePreservative (example): Substance added to specimen container.
condition	Σ	0..*	CodeableConcept	State of the specimen Binding: hl7VS-specimenCondition (extensible): Codes describing the state of the specimen.
note	S	0..*	Annotation	Comments
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet
Specimen.language	preferred	CommonLanguages Additional Bindings Purpose AllLanguages Max Binding
Specimen.status	required	SpecimenStatus
Specimen.type	example	Hl7VSSpecimenType
Specimen.type.coding:sct	extensible	ValueSetProbenart
Specimen.collection.duration	extensible	CommonUCUMCodesForDuration Additional Bindings Purpose AllUCUMExpressionForTime Max Binding
Specimen.collection.method	example	FHIRSpecimenCollectionMethod
Specimen.collection.bodySite	example	SNOMEDCTBodyStructures
Specimen.collection.bodySite.coding:sct	required	ValueSetSCTBodyStructures
Specimen.collection.bodySite.coding:icd-o-3	required	ValueSetICDO3Topography
Specimen.collection.fastingStatus[x]	extensible	Hl7VSRelevantClincialInformation
Specimen.collection.fastingStatus[x]:fastingStatusCodeableConcept	required	Hl7VSRelevantClincialInformation
Specimen.processing.procedure	example	ValueSetSCTLaboratoryProcedure
Specimen.processing:lagerprozess.procedure	example	SpecimenProcessingProcedure
Specimen.container.type	extensible	ValueSetContainertyp
Specimen.container.additive[x]	example	Hl7VSAdditivePreservative
Specimen.condition	extensible	Hl7VSSpecimenCondition

Constraints

Id	Grade	Path(s)	Details	Requirements
dom-2	error	Specimen	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	Specimen	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	Specimen	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	Specimen	A resource should have narrative for robust management : text.`div`.exists()
drt-1	error	Specimen.collection.duration	There SHALL be a code if there is a value and it SHALL be an expression of time. If system is present, it SHALL be UCUM. : code.exists() implies ((system = %ucum) and value.exists())
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** elements	Must have either extensions or value[x], not both : extension.exists() != value.exists()
mii-bb-1	error	Specimen.collection.bodySite	Bei der Angabe der Entnahmestelle muss ein ICD-O-3 Topographiecode oder ein SNOMED CT Code angegeben werden. : coding.where(system = 'http://snomed.info/sct' or system = 'http://terminology.hl7.org/CodeSystem/icd-o-3').exists()
qty-3	error	Specimen.collection.duration, Specimen.collection.quantity, Specimen.container.capacity, Specimen.container.specimenQuantity	If a code for the unit is present, the system SHALL also be present : code.empty() or system.exists()
ref-1	error	Specimen.subject, Specimen.parent, Specimen.request, Specimen.collection.collector, Specimen.processing.additive, Specimen.processing:lagerprozess.additive	SHALL have a contained resource if a local reference is provided : reference.startsWith('#').not() or (reference.substring(1).trace('url') in %rootResource.contained.id.trace('ids'))
sqty-1	error	Specimen.collection.quantity, Specimen.container.capacity, Specimen.container.specimenQuantity	The comparator is not used on a SimpleQuantity : comparator.empty()